Professor Brody
Jeff Goldblum
Mrs. Brody
Elizabeth Perkins
Calico (voice)
Jon Lovitz
The Mastiff (voice)
Charlton Heston
Russian Blue (voice)
Glenn Ficarra
Ninja Cat #1 (voice)
Billy West
Ginger Kitten (voice)
John Michael Higgins
Puppy in Barn (voice)
Richard Steven Horvitz
Buddy (voice)
Frank Welker
The Farmer
Frank C. Turner
Pie Mom (as Kirsten Robek)
Lauren K. Robek
Guard at Gate
Mar Andersons
Scotty Brody
Alexander Pollock
Factory Receptionist
Gillian Barber
Sophie's Sister
Carol Ann Susi
Randi Kaplan
Mary Bogue
Mason Employee
Alvin Sanders
Mark Schooley
Worker
Lou Bollo
Scott Nicholson
Trish Schill
Wife Passenger
Babe Dolan
Sophie the Castle Maid
Miriam Margolyes
Truck Driver (as Reginald Glass)
Reg Glass
Truck Driver
Charles Andre
Nurse
Peggy Logan
Jogger
Alicia Michelle
Yorkie Dog Owner
Pamela Perry
Doberman Drill Sergeant (voice)
Victor Wilson
Collie at HQ (voice)
Salome Jens
Ninja Cat (voice)
Danny Mann
Wolf Blitzer (voice)
Paul Pape
Lou the Beagle (voice)
Tobey Maguire
Mr. Mason
Myron Natwick
Mrs. Calvert
Doris Chillcott
Butch (voice)
Alec Baldwin
Mr. Tinkles (voice)
Sean Hayes
Ivy (voice)
Susan Sarandon
Peek (voice)
Joe Pantoliano
Sam (voice)
Michael Clarke Duncan
Stunt Coordinator
J.J. Makaro
Executive Producer
Chris Bender
Screenplay
John Requa
First Assistant Editor
Jason Tucker
Bruce Berman
Supervising Dialogue Editor
Mark Mangini
J.C. Spink
Original Music Composer
John Debney
Visual Effects Supervisor
Bill Westenhofer
Producer
Christopher DeFaria
Craig Barron
Production Design
James D. Bissell
Director
Lawrence Guterman
Director of Photography
Julio Macat
Editor
Rick Finney
Animation
Eric Oliver
Storyboard
Bob Camp
Michael A. Stevenson
Costume Design
Tish Monaghan
Andrew Lazar
Craig Perry
Warren Zide
Digital Compositor
John Slattery