Henry Louis 'Lou' Gehrig
Gary Cooper
Eleanor Twitchell
Teresa Wright
Mr. Twitchell
Pierre Watkin
Orchestra Leader (uncredited)
Ray Noble
Scrubwoman (uncredited)
Patsy O'Byrne
Freshman (uncredited)
George Offerman, Jr.
Reporter (uncredited)
John B. Old
Scorecard Vendor (uncredited)
Garry Owen
Mrs. Roberts (uncredited)
Sarah Padden
Chicago Policeman O'Doul (uncredited)
Emory Parnell
Policeman (uncredited)
Edward Peil Sr.
Reporter in Hospital (uncredited)
Tom Quinn
Photographer (uncredited)
Cyril Ring
Joe McCarthy
Harry Harvey
Disappointed Fan #2 (uncredited)
Henry Roquemore
Telephone Man (uncredited)
Art Rowlands
Joe Fabrini (uncredited)
William Roy
Laddie (uncredited)
Rip Russell
Cab Driver (uncredited)
Francis Sayles
Sasha's Mother (uncredited)
Anita Sharp-Bolster
Mr. Worthington (uncredited)
C. Montague Shaw
Hammond (uncredited)
Jack Shea
First Paper Hanger (uncredited)
John Sheehan
Ed Barrow (uncredited)
Jack Stewart
Robert W. Meusel (as Robert W. Meusel)
Bob Meusel
Brick Sullivan
Conductor (uncredited)
Ben Taggart
Cake Delivery Boy (uncredited)
Walter Tetley
Sasha - Boy Playing Baseball (uncredited)
Jimmy Valentine
Furniture Mover (uncredited)
Gohr Van Vleck
Eleanor's Landlady (uncredited)
Dorothy Vaughan
Family Friend (uncredited)
Dorothy Vernon
Big Strength Machine Contestant (uncredited)
Malcolm Waite
Spectator (uncredited)
James Westerfield
Sportsman at Ballgame (uncredited)
Guy Wilkerson
Mark Koenig
Mr. Colletti (uncredited)
Max Willenz
Bootblack (uncredited)
Buddy Williams
Little Strength Machine Contestant (uncredited)
Charles Williams
Murphy (uncredited)
Robert Winkler
Allen Wood
Mike Donovan
Radio Listener (uncredited)
Dick Gordon
Fraternity Boy (uncredited)
Charles Flynn
Jack Gardner
Merril (uncredited)
Anthony Walters
Bill Stern
Coach
Addison Richards
Van Tuyl
Hardie Albright
Clinic Doctor
Edward Fielding
Mayor of New Rochelle
George Lessey
Hospital Doctor
Edgar Barrier
Babe Ruth
Lou Gehrig as a Boy
Douglas Croft
Billy (Age 8)
Gene Collins
Billy (Age 17)
David Holt
Specialty Dancer (as Veloz and Yolanda)
Veloz
Yolanda
Barber (uncredited)
Ed Agresti
Bellhop with Flowers (uncredited)
Ernie Alexander
Lathered Man in Barber Shop (uncredited)
Hooper Atchley
Restaurant Patron (uncredited)
Edwin August
Nightclub Singer (uncredited)
Bettye Avery
Sam Blake
Walter Brennan
Little Girl (uncredited)
Becky Bohanon
Photographer in Hospital (uncredited)
Lynton Brent
Yankee Ballplayer (uncredited)
Roy Brent
Betty Brewer
Girl Show Barker (uncredited)
Don Brodie
Plumber (uncredited)
Charles Cane
Jack Carr
Village Storekeeper (uncredited)
Burr Caruth
Motorcycle Cop #2 (uncredited)
Eddy Chandler
Mark - Player in Locker Room (uncredited)
Lane Chandler
Hank Hanneman
Dan Duryea
Newsboy (uncredited)
Bill Chaney
Jack Chapin
Tessie (uncredited)
Janet Chapman
Mr. Larsen (uncredited)
Spencer Charters
Weight Guesser (uncredited)
Porter Chase
Dane Clark
Wallpaper Hanger (uncredited)
Heinie Conklin
Man in Cab (uncredited)
Hal Cooke
Motorcycle Cop #1 (uncredited)
Clancy Cooper
John Daheim
Christina 'Mom' Gehrig
Elsa Janssen
Mrs. Worthington (uncredited)
Eva Dennison
Disappointed Fan #1 (uncredited)
Lester Dorr
Peter Du Rey
Clinic Nurse (uncredited)
Lorna Dunn
Jim Farley
Yankee Third Base Coach (uncredited)
Frank Faylen
Dentist (uncredited)
Walter Fenner
Pat Flaherty
Mrs. Fabrini (uncredited)
Rosina Galli
Doctor in Gehrig Home (uncredited)
Vaughan Glaser
Henry 'Pop' Gehrig
Ludwig Stössel
Maid (uncredited)
Mary Gordon
Herschel Graham
Second Paper Hanger (uncredited)
George Guhl
Reporter in Hospital Room (uncredited)
Eddie Hall
Department Store Manager (uncredited)
Harry Hayden
Vinton Hayworth
Oscar 'Dutch' Hendrian
Announcer (uncredited)
John Hiestand
Bottle Game Operator (uncredited)
Earle Hodgins
Myra Tinsley
Virginia Gilmore
Fay Holderness
Man in Box Seat (uncredited)
John Ince
Mitchell Ingraham
Carnival Batting Game Operator (uncredited)
Charles Irwin
Jack Irwin
Sheldon Jett
Boy in Ball Park (uncredited)
Payne B. Johnson
John Kellogg
Yankee Player on Train (uncredited)
Colin Kenny
Donald Kerr
Bill Dickey
Broker (uncredited)
Richard Kipling
Wheel of Chance Barker (uncredited)
Pat Lane
Barker (uncredited)
Larry Lawson
Rex Lease
Neighbor Leaning Through Window (uncredited)
Theodore Lorch
Frank Lyman
Man Outside Yankee Stadium (uncredited)
Wilbur Mack
Mayor Fiorello LaGuardia (uncredited)
Dave Manley
Player (uncredited)
Maurice Marks
Rathskeller Headwaiter (uncredited)
Francisco Marán
Miller Huggins
Ernie Adams
Minor Role (uncredited)
John C. McCallum
Ralph McCullough
Wally Pipp (uncredited)
George McDonald
Strength Machine Operator (uncredited)
Matt McHugh
Rathskeller Manager (uncredited)
James McNamara
Wilmuth Merkyl
Howard M. Mitchell
Headwaiter (uncredited)
Irving Mitchell
Policeman in 1915 (uncredited)
Pat Moriarity
Tom Neal
Production Design
William Cameron Menzies
Director of Photography
Rudolph Maté
Producer
Samuel Goldwyn
Songs
Irving Berlin
Editor
Daniel Mandell
Original Music Composer
Leigh Harline
Director
Sam Wood
Screenplay
Jo Swerling
Herman J. Mankiewicz
Music Arranger
Fletcher Henderson
Makeup Artist
Norbert A. Myles
Stunts
Original Story
Paul Gallico
Set Decoration
Howard Bristol
Assistant Director
John Sherwood
Sound Recordist
Frank Maher
Art Direction
Perry Ferguson
Costume Design
René Hubert
Mel Berns
Matte Painter
Albert Simpson