Jimmy Neutron / Alien Actress / Alien Woman (voice)

Debi Derryberry

Carl Wheezer/Mr. Wheezer/Mrs. Wheezer/Test Pilot/Announcer (voice)

Rob Paulsen

Judy Neutron / Mrs. Vortex (voice)

Megan Cavanagh

Brain #2 / Mayor Quadar (voice)

Jim Cummings

Hugh Neutron / Emergency System / Gen. Abercrombie (voice)

Mark DeCarlo

Meldar Prime (singing voice)

Jess Harnell

Sr. Estevez (voice)

Joe Lala

Bolbi Stroganofsky / British Tourist (voice)

Phil LaMarr

Sam / Corky Shumatsu (voice)

Billy West

Vendanna (voice)

Grey DeLisle

Sheen Estevez / Army Guard (voice)

Jeffrey Garcia

Goddard (voice)

Frank Welker

Cindy Vortex (voice)

Carolyn Lawrence

Libby Folfax (voice)

Crystal Scales

Meldar Prime (voice)

Tim Allen

April (voice)

Alyssa Milano

Sr. Estevez (voice)

Carlos Alazraqui

Gorlock #2 / Brain #1 (voice)

Jeff Bennett

Executive Producer

Steve Oedekerk

Layout Supervisor

Joseph P. Johnston

Director

Mike Gasaway

Music

Charlie Brissette