Cleopatra
Claudette Colbert
Julius Caesar
Warren William
Cassius
Ian Maclaren
Charmion
Eleanor Phelps
Pothinos
Leonard Mudie
Iras
Grace Durkin
Glabrio (scenes deleted)
Ferdinand Gottschalk
Octavia
Claudia Dell
Soothsayer
Harry Beresford
Lady Vesta
Jayne Regan
Lepidus
William Farnum
Fidius
Lionel Belmore
Marc Antony
Henry Wilcoxon
Lady Flora
Florence Roberts
General Philodemas
Richard Alexander
Lady Leda
Celia Ryland
Court Physician
William V. Mong
General Achillas
Robert Warwick
Courier
George Walsh
Scribe
Kenneth Gibson
Wedgwood Nowell
Bruce Warren
Aelius (as Robert Manning)
Robert Seiter
King Herod
Joseph Schildkraut
Convict
Edgar Dearing
Roman Citizen/Party Guest/Soldier (uncredited) (voice)
John Carradine
Roman Greeting Antony (uncredited)
Wilfred Lucas
Slave (uncredited)
David Niven
Slave Girl (uncredited)
Olga Celeste
Octavian
Ian Keith
Calpurnia
Gertrude Michael
Enobarbus
C. Aubrey Smith
Apollodorus
Irving Pichel
Brutus
Arthur Hohl
Casca
Edwin Maxwell
Camera Operator
William C. Mellor
Assistant Director
Cullen Tate
Screenplay
Waldemar Young
Props
Michael D. Moore
Researcher
Jeanie Macpherson
Director
Cecil B. DeMille
Producer
Costume Design
Travis Banton
Presenter
Adolph Zukor
Editor
Anne Bauchens
Original Music Composer
Rudolph G. Kopp
Art Direction
Roland Anderson
Hans Dreier
Casting
Billy Gordon
Director of Photography
Victor Milner
Vicky Williams
David MacDonald
Vincent Lawrence
Adaptation
Bartlett Cormack
Assistant Camera
Robert Rhea
Special Effects
Barney Wolff
Still Photographer
Ray Jones
Gladys Percey
Sound Effects Editor
Treg Brown
Orchestrator
Max Reese
Milan Roder
Sound Director
Franklin Hansen
Sculptor
Ralph Jester
Guy Roe
Cooper Smith
Music Director
Nat W. Finston
Stand In
Gladys Jeans
Cliff Shirpser
Sound Engineer
Harry Lindgren