Sherlock Holmes (voice)
Michael York
Professor Moriarity (voice)
Malcolm McDowell
Ali / First Policeman (voice)
Richard McGonagle
Dr. Watson (voice)
John Rhys-Davies
Tom (voice)
Billy West
Red (voice)
Grey DeLisle
Spike / Policeman (voice)
Phil LaMarr
Tuffy (voice)
Kath Soucie
Butch / Droopy (voice)
Jeff Bergman
Tin / Sergeant (voice)
Greg Ellis
Pan / Brett Jeremy (voice)
Jess Harnell
Executive Producer
William Hanna
Creative Producer
Characters
Director
Spike Brandt
Arthur Conan Doyle
Joseph Barbera
Jeff Siergey
Screenplay
Earl Kress
Color Designer
Sylvia Filcak
Animation Director
Kevin M. O'Neil
Layout
Roberto Casale
Original Music Composer
Michael Tavera