Peter Griffin / Stewie Griffin / Stan Smith (voice)
Seth MacFarlane
Chris Griffin (voice)
Seth Green
Rupert (voice)
David Boat
Cancer Sufferer (voice) (as Alex Breckenridge)
Alexandra Breckenridge
Judge (voice)
Phil LaMarr
Mayor Adam West (voice)
Adam West
Willem Dafoe (voice)
David Anthony Pizzuto
Lois Griffin (voice)
Alex Borstein
Meg Griffin (voice)
Mila Kunis
Cleveland Brown / Bruce / Jeffry / Consuela (voice)
Mike Henry
Joe Swanson (voice)
Patrick Warburton
Avery Bullock (voice)
Patrick Stewart
Himself (voice)
Simon Cowell
Herself (voice)
Paula Abdul
Randy Jackson
Director
Greg Colton
John Holmquist