Cpt. Meriwether Lewis
Fred MacMurray
Lt. William Clark
Charlton Heston
Shoshone Woman (uncredited)
Argentina Brunetti
Crow Woman (uncredited)
Julia Montoya
Chief Le Borgne (uncredited)
Ralph Moody
Night Camp Sentry (uncredited)
William Phipps
Helmsman Cruzatte (uncredited)
Walter Reed
Tom (uncredited)
Bill Walker
Mrs. Martha Hancock (uncredited)
Helen Wallace
Sacajawea
Donna Reed
Julia Hancock
Barbara Hale
Sgt. Gass
William Demarest
Charbonneau
Alan Reed
Chief Cameahwait
Eduardo Noriega
Wild Eagle
Larry Pennell
President Thomas Jefferson
Herbert Heyes
Mr. Hancock
Lester Matthews
Stunts
Bob Herron
Makeup Supervisor
Wally Westmore
Director of Photography
Daniel L. Fapp
Director
Rudolph Maté
Costume Design
Edith Head
Set Decoration
Sam Comer
Screenplay
Winston Miller
Edmund H. North
Original Music Composer
Hans J. Salter
Art Direction
Hal Pereira
A. Earl Hedrick
Second Unit Director of Photography
William Williams
Visual Effects
John P. Fulton
Otto Siegel
Second Unit Director
Charles C. Coleman
Assistant Director
William McGarry
Technical Advisor
Donald R. O. Hatswell
Sound Recordist
Gene Merritt
Gene Garvin
Producer
William H. Pine
William C. Thomas
Novel
Della Gould Emmons
Editor
Frank Bracht