Dr. Watson, who served in the English armed forces and was in the Afghan war, retires and returns to his homeland, in England. Since the financial situation of the doctor is very precarious, his long-time friend Mr. Stamford offers him to rent a room in the house at 221-B Baker Street, which is rented by an elderly lady - Mrs. Hudson. The second rented room is already occupied by another gentleman - the mysterious Mr. Sherlock Holmes. Holmes makes an ambiguous impression on Watson. He conducts complex chemical experiments with blood, plays the violin, has the deepest knowledge about cigar ash, London dirt and criminal law, but at the same time demonstrates complete ignorance of well-known truths (for example, the fact that the Earth revolves around the Sun), does not read fiction, as well as books on history and philosophy. At the same time, very strange visitors constantly come to Holmes, and on the table he has portraits of personalities of a disgusting appearance.

Arthur Conan Doyle reveals the story behind Sherlock Holmes and his mysteries by telling about Dr. Joseph Bell, from whom he drew his inspiration, after meeting him as a medical student in Edinburgh. This TV movie served as the pilot for the later released minisseries Murder Rooms: Mysteries of the Real Sherlock Holmes produced by the BBC. The series then picks up with Sir Arthur Conan Doyle's time as a general practitioner in Southsea, solving mysteries with the help of his mentor, Dr Joseph Bell, who is still based in Edinburgh. The series name in the pilot was Mr Bell and Mr Doyle instead Murder Rooms. Some of the cast of the pilot was also changed in the series.

Now a detective-for-hire like her infamous brother, Enola Holmes takes on her first official case to find a missing girl, as the sparks of a dangerous conspiracy ignite a mystery that requires the help of friends — and Sherlock himself — to unravel.

While searching for her missing mother, intrepid teen Enola Holmes uses her sleuthing skills to outsmart big brother Sherlock and help a runaway lord.

Mary Morstan has received a pearl in the post every year since her father's disappearance. This leads Holmes and Watson to the truth about a secret pact between four convicts during the Indian Rebellion of 1857.

During WWII several murders occur at a convalescent home where Dr. Watson has volunteered his services. He summons Holmes for help and the master detective proceeds to solve the crime from a long list of suspects including the owners of the home, the staff and the patients recovering there.

In World War II, a British secret agent carrying a vitally important document is kidnapped en route to Washington. The British government calls on Sherlock Holmes to recover it.

Sherlock Holmes comes to the aid of his friend Henry Baskerville, who is under a family curse and menaced by a demonic dog that prowls the bogs near his estate and murders people.

England, at the start of World War Two. Mysterious wireless broadcasts, apparently from Nazi Germany are heard over the BBC. They warn of acts of terror in England, just before they take place. Baffled, the Defense Committee call in Sherlock Holmes.

A beautiful young woman asks Holmes to help her father, a former army captain and hopeless opium addict break free of the curse surrounding a stolen treasure.

On his uncle's death Sir Henry Baskerville returns from abroad and opens up the ancestral hall on the desolate moors of Devonshire. Holmes uncovers a plot to have Sir Henry murdered by a terrible trained hound.

Sherlock Holmes has retired. But when MacDonald asks him to take on another case, he says yes. There have been some mysterious murders, and there are no visible causes for the deaths. At the same time Holmes gets this case, Graf Udo Von Felseck gives him another case: find a young and missing prince to prevent war between Germany and England. But Von Felseck is not as honest as he seems...

A card cheat is threatened with exposure into joining a criminal enterprise that Sherlock Holmes believes is controlled by Professor Moriarity.

Moriarty is sentenced to death, and Sherlock Holmes prepares to retire to the country and marry his girl. But Moriarty has sworn that Holmes, Lt. Col. Gore-King of Scotland Yard, and his trial judge shall all be hanged too. When Moriarty escapes and proceeds to put his threat into operation, Holmes has to postpone his retirement.

A young woman turns to Holmes for protection when she's menaced by an escaped killer seeking missing treasure. However, when the woman is kidnapped, Holmes and Watson must penetrate the city's criminal underworld to find her.

Detective Sherlock Holmes and Dr. John Watson join forces to investigate a mysterious murder at Buckingham Palace. It seems like an open-and-shut case as all signs point to Professor James Moriarty, the criminal mastermind and longtime nemesis of the crime-solving duo. When new twists and clues begin to emerge, the world's greatest sleuth and his trusted assistant must now use their legendary wits and ingenious methods to catch the killer as they only have four days before the queen becomes the next victim.

The sensational details of a gruesome murder in The Daily Gazette have London in a panic, as a blood-thirsty madman - more vicious than Jack the Ripper - preys upon the city. Of greater concern to Scotland Yard, however, is that the account of the murder was published nearly two hours prior to the crime having been committed! Sherlock Holmes and Dr. Watson - the Great Detective and his faithful assistant and chronicler - find themselves challenged with one of their most baffling cases - "The Case of the Woman Who Was Murdered Tomorrow"! Will an innocent man be sent to the gallows? How much blood will be shed before a scarred fiend is brought to justice? ...And who are the mysterious Shadow Watchers, a coven of ominous figures who orchestrate terror from within the darkness? Starring Anthony D.P. Mann as Holmes and Terry Wade as Dr. Watson, "Sherlock Holmes and the Shadow Watchers" is a horrifying new adventure, produced with the kind permission of the Conan Doyle Estate*.

Sherlock Holmes is forced to confront his age and health condition as he struggles to solve the murder of a fellow detective.

A wealthy banker comes to Holmes desperate to recover a valuable British gem--and to deal with his son's apparent dishonor.

Sherlock Holmes gets the clues he needs to solve a murder, and to prevent another one from occurring, when he finds out that a doctor owns a poisonous snake--the deadly swamp adder. Filmed on the expensive sets leftover from the movie Joan of Arc at Hal Roach Studios in Culver City and produced for the "Your Show Time" series, the short has been released as a solo feature on many DVDs that chronicle classic Sherlock Holmes films..