Dr. Watson, who served in the English armed forces and was in the Afghan war, retires and returns to his homeland, in England. Since the financial situation of the doctor is very precarious, his long-time friend Mr. Stamford offers him to rent a room in the house at 221-B Baker Street, which is rented by an elderly lady - Mrs. Hudson. The second rented room is already occupied by another gentleman - the mysterious Mr. Sherlock Holmes. Holmes makes an ambiguous impression on Watson. He conducts complex chemical experiments with blood, plays the violin, has the deepest knowledge about cigar ash, London dirt and criminal law, but at the same time demonstrates complete ignorance of well-known truths (for example, the fact that the Earth revolves around the Sun), does not read fiction, as well as books on history and philosophy. At the same time, very strange visitors constantly come to Holmes, and on the table he has portraits of personalities of a disgusting appearance.

On his uncle's death Sir Henry Baskerville returns from Canada to take charge of his ancestral hall on the desolate moors of Devonshire, and finds that Sherlock Holmes is there to investigate the local belief that his uncle was killed by a monster hound that has roamed the moors since 1650, and is likely to strike again at Sir Henry.

After the death of his wife, wealthy retiree Justin Playfair creates a fantasy world for himself in which he is the legendary detective Sherlock Holmes, even dressing like the character. Out of concern for Justin's money more than his health, his brother Blevins puts him under the care of psychiatrist Dr. Mildred Watson. As Dr. Watson grows fond of Justin, she begins to play along with his theories, eventually becoming an assistant in his investigations.

In World War II, a British secret agent carrying a vitally important document is kidnapped en route to Washington. The British government calls on Sherlock Holmes to recover it.

England, at the start of World War Two. Mysterious wireless broadcasts, apparently from Nazi Germany are heard over the BBC. They warn of acts of terror in England, just before they take place. Baffled, the Defense Committee call in Sherlock Holmes.

Tom and Jerry need to learn to work together in order to help Sherlock Holmes with an investigation of a jewel theft. But still, they are cat and mouse!

When Watson reads from the newspaper there have been two similar murders near Whitechapel in a few days, Sherlock Holmes' sharp deductive is immediately stimulated to start its merciless method of elimination after observation of every apparently meaningless detail. He guesses right the victims must be street whores, and doesn't need long to work his way trough a pawn shop, an aristocratic family's stately home, a hospital and of course the potential suspects and (even unknowing) witnesses who are the cast of the gradually unraveled story of the murderer and his motive.

Concerned about his friend's cocaine use, Dr. Watson tricks Sherlock Holmes into travelling to Vienna, where Holmes enters the care of Sigmund Freud. Freud attempts to solve the mysteries of Holmes' subconscious, while Holmes devotes himself to solving a mystery involving the kidnapping of Lola Deveraux.

After spending decades living in the shadow of his more famous and successful sibling, Consulting Detective Sigerson Holmes (Wilder) is called upon to help solve a crucial case that leads him on a hilarious trail of false identities, stolen documents, secret codes... and exposed backsides.

In London, a secret society led by lawyer Thaddeus Merrydew collects the assets of any of its deceased members and divides them among the remaining members. Society members start dropping like flies. Sherlock Holmes is approached by member James Murphy's widow, who is miffed at being left penniless by her husband. When Captain Pyke is shot, Holmes keys in on his mysterious Chinese widow as well as the shady Merrydew. Other members keep dying: Malcom Dearing first, then Mr. Baker. There is also an attempt on the life of young Eileen Forrester, who became a reluctant society member upon the death of her father. Holmes' uncanny observations and insights are put to the test.

Holmes takes a vacation and visits his old friend Sir Henry Baskerville. His vacation ends when he suddenly finds himself in the middle of a double-murder mystery. Now he's got to find Professor Moriarty and the horse Silver Blaze before the great cup final horse race.

A young woman turns to Holmes for protection when she's menaced by an escaped killer seeking missing treasure. However, when the woman is kidnapped, Holmes and Watson must penetrate the city's criminal underworld to find her.

Sherlock Holmes is forced to confront his age and health condition as he struggles to solve the murder of a fellow detective.

Holmes receives a mysterious telegram from Cyril Overton, the captain of the Cambridge University rugby team. Overton later explains that one of the best players on his team, a young man named Godfrey Staunton, went missing while in London for an important game. Holmes follows a trail of clues back to Cambridge.

A governess is arrested for the murder of her employer's wife.

A gentleman is baffled when the childish drawings of little dancing men terrify his American wife. Sherlock Holmes soon discovers why.

Susan Cushing asks Holmes' help in solving the disappearance of her sister Mary Browner, but it doesn't seem Holmes' type of case until he is told of a Christmas present's grisly contents.

Hilton Soames, a lecturer in Greek at a university, notices that someone has gone into his study and looked at the text for an unseen translation exam that is due to take place the next day. Suspicion falls on the three students who live in the same building in which Soames lives and works, all of whom are entered for the exam.

A German spy named Von Bork has been in England since 1910. Through several agents, he has gathered a significant amount of information relating to the British armed forces and foreign policy. He is unaware that a large amount of that information is false because one of his agents is really Sherlock Holmes, who is working for the British government.

Dr. John Watson treats a patient who has lost a thumb. The patient says that the loss of his thumb was not an accident but the result of an attack. However, he fears that the story behind the loss of his digit is so strange that the police will not believe it.