Tarzan welcomes back Dr. Ken Warwick whose been away studying medicine for two years. There's trouble brewing however when the local witch doctor, Futa, sees his influence with the villagers waning in favor of the local clinic run by Dr. Sturdy and Dr. Warwick. The tribal chief has died and when his son and heir falls ill, Futa decides he is the one who has to treat him. Futa's henchman, Ramo, steals what he thinks is medicine but is actually a deadly serum. If given to the boy-chief, he will surely die. It's left to Tarzan to try and avert tragedy

Dr. Brooks is captured by followers of Zar, God of the Jeweled Fingers, but he is soon rescued from their lost city by Tarzan, a while man who was raised in the jungle by apes and speaks no English to speak of. But Tarzan undertakes to locate Brooks' daughter Mary after seeing a photograph of her. Meanwhile, back in the jungle, Mary and Bob Hall are searching for her father. Their guides, Jeff and Nick, are more interested in finding the treasure of Zar and scoring with Mary than finding Dr.Brooks. Jeff is in the possession of a message offering a large reward for Tarzan --- dead or alive. A group of Arabs, also captivated by Mary, accompany the searchers. Following a series of plots and counterplots, foiled by Tarzan, all hands are eventually captured by the followers of Zar. Jeff and Nick are killed and the survivors promise never to return to the Lost City. Mary decides to remain in the jungle as she has become quite fond of quaffing grapes in a cave with Tarzan