A group of people traveling on a stagecoach find their journey complicated by the threat of Geronimo, and learn something about each other in the process.

In Arizona in the late 1800s, infamous outlaw Ben Wade and his vicious gang of thieves and murderers have plagued the Southern Railroad. When Wade is captured, Civil War veteran Dan Evans, struggling to survive on his drought-plagued ranch, volunteers to deliver him alive to the "3:10 to Yuma", a train that will take the killer to trial.

After the train station clerk is assaulted and left bound and gagged, then the departing train and its passengers robbed, a posse goes in hot pursuit of the fleeing bandits.

Three outlaws come to the aid of a young girl after her father is killed.

Delos is a futuristic amusement park that features themed worlds—ancient Rome, Medieval times and the Old West—populated by human-like androids. After two patrons have a run-in with a menacing gunslinger in West World, the androids at Delos all begin to malfunction, causing havoc throughout the park.

On the way to pick up the bounty on a wanted murderer, a bounty hunter stops at a staging post where he is forced to continue his journey with two outlaws who want the murderer for their own reasons and a recently-widowed woman, with the murderer's brother and his men in hot pursuit.

Outlaw and self-appointed lawmaker Judge Roy Bean rules over an empty stretch of the West that gradually grows, under his iron fist, into a thriving town, while dispensing his his own quirky brand of frontier justice upon strangers passing by.

Marshal Wyatt Earp kills a couple of men of the Clanton-gang in a fight. In revenge Clanton's thugs kill the marshal's brother. Thus, Wyatt Earp starts to chase the killers together with his friend Doc Holliday.

Stodge City is in the grip of the Rumpo Kid and his gang. Mistaken identity again takes a hand as a 'sanitary engineer' named Marshal P. Knutt is mistaken for a law marshal. Being the conscientious sort, Marshal tries to help the town get rid of Rumpo, and a showdown is inevitable. Marshal has two aids—revenge-seeking Annie Oakley and his sanitary expertise.

Ben Wade and his partner Frosty return to Bellounds' ranch where twenty years earlier Wade was wanted for murder. Unrecognized, he gets a job on the ranch and soon becomes involved in Folsom's cattle rustling and a chance to settle an old score.

The cattle herds of some Arizona ranchers are being stampeded and stolen, so the Arizona Stockmen's Syndicate sends ace investigator Steve Reynolds in to find out who is responsible. Steve poses as a vicious gunslinger named Buck McCloud to work his way into the gang, and then becomes the Durango Kid to disrupt the activities he learns about. Jud Temple is the loyal fiancée of town banker Grat Hanlon who turns out to be the brain-trust behind the gang.

Calamity Jane is a tough and rowdy woman in the old West who owns a saloon and gambling joint (and runs a cattle rustling operation as a sideline). One day she hires a pretty but naive young woman to work as a saloon girl, and finds that the girl is bringing out the maternal instincts she never knew she had. Those instincts are put to the test when a US army cavalry troop arrives to clean up the town and the girl and the young lieutenant in charge of the troop fall in love, and Calamity Jane may know something about the lieutenant that the girl doesn't.

Henry Moon is captured for a capital offense by a posse when his horse quits while trying to escape to Mexico. He finds that there is a post-Civil War law in the small town that any single or widowed woman can save him from the gallows by marrying him.

Karl Westover, an inexperienced farm boy, runs away after unintentionally killing a neighbor, whose family pursues him for vengeance. He meets Barbarosa, a gunman of near-mythical proportions, who is himself in danger from his father-in-law Don Braulio, a wealthy Mexican rancher. Don Braulio wants Barbarosa dead for marrying his daughter against the father's will. Barbarosa reluctantly takes the clumsy Karl on as a partner, as both of them look to survive the forces lining up against them.

An outlaw gang is trying to stop the reopening of a mine as they look for the money left there by the famous outlaw Dusty Morton. After a ten year absence, Morton has apparently reappeared and Steve arrives looking for him. He finds his son who also wonders if his father is still alive. With the gang soon after him, the Durango Kid goes into action and Steve tries to learn who the real Dusty Morgan is.

Brett runs a protection racket for an unknown boss. When Jeff Hayes arrives and opens a gambling den, they try to shut him down. Unlike the others who have given in, he plans to fight back.

Fuzzy purchases a saloon with a large sack of gold from the mine he owns with his partner Billy. When a crooked lawyer uses underhanded methods to try taking over the saloon, Billy works to bring the lawyer and his no-good gang to justice.

Cowboy infiltrates an outlaw gang to expose their rackets, but after he's ordered to kidnap a young girl, the gang finds out who he really is.

An Arizona Ranger's investigation results in his having to arrest the brother of the girl he loves.

Night riders are terrorizing homesteaders, and the town doctor tries to keep the locals from forming a vigilante group. After more towns people are killed, however, the rest of the town makes the doctor the town sheriff and tells him to clean up the gang.