Eugene, an aspiring writer from Brooklyn, is drafted into the US Army during the final months of World War II. For his basic training, the Army sends him to Camp Shelby in Mississippi, where toil, bad food, and antisemitic jibes await. Eugene takes refuge in his sense of humor and in his diary, but they won't protect him in a battle of wills with an unstable drill sergeant.

Dr. Malcolm Sayer, a shy research physician, uses an experimental drug to "awaken" the catatonic victims of a rare disease. Leonard is the first patient to receive the controversial treatment. His awakening, filled with awe and enthusiasm, proves a rebirth for Sayer too, as the exuberant patient reveals life's simple but unutterably sweet pleasures to the introverted doctor.