In early-1970s Las Vegas, Sam "Ace" Rothstein gets tapped by his bosses to head the Tangiers Casino. At first, he's a great success in the job, but over the years, problems with his loose-cannon enforcer Nicky Santoro, his ex-hustler wife Ginger, her con-artist ex Lester Diamond and a handful of corrupt politicians put Sam in ever-increasing danger.

The wife and mistress of a cruel school master collaborate in a carefully planned and executed scheme to murder him. The plan goes well until the body, which has been strategically dumped, disappears. The psychological strain starts to weigh on the two women when a retired police investigator begins looking into the man's disappearance on a whim.