Madhavan (Dileep) is a clever thief who does robbery for a living. He is following the principles of his mentor Mullani Pappan (Mala Aravindan). Meesa Madhavan got his name by the popular saying that if Madhavan rolls his Mustache (Meesa in Malayalam) looking at someone, he will rob his house that night. His enemy was a local money lender Bhageerathan Pillai (Jagathy Sreekumar) who refused to give back his father's property. Madhavan falls in love in Bhageerathan Pillai's daughter Rukmini (Kavya Madhavan). The sub inspector in the village Eappen Pappachi (Indrajith) has an eye on Rukmini. He steals the idol from the local Temple with the intention of selling it and puts the blame on Madhavan. It becomes Madhavan's responsibility to find the culprits and he does that with his mentor's help and thus uniting with his girl friend.

The story revolves around the college graduate class of 1992. In 2006, working in different corners of the world, the friends get together for a class reunion to revive the joy and laughter of their student days. Shockingly, on the night of the reunion, one of the classmates is almost murdered and goes into a coma.

After years spent living off the modest wealth of his in-laws, a man hatches a desperate plan that draws his respectable middle-class family into a vortex of crime.

Movie narrates the story of a couple, Akash and Vani. They go on a personal trip to spend some quality time with each other and the resulting incidents are plotted.

In the ancient village of Shivapuram, little Ananthan hears a tale from his mother, Gayathri (Revathi). She tells him that his family comes from a line of powerful magicians, and they are responsible for protecting nagamanikyam, a jewel on a serpent's head. The jewel, she narrates, lies in a secret place in the house guarded by snakes, including a tiny snake called Kunjootan. Years later, obeying the wishes of his dead mother, Ananthan (Prithviraj Sukumaran) returns to his ancestral village to light the lamps at Shivakavu, a dark and mysterious temple of Shiva.