Matt Hobbs is a talented but unsuccessful actor. When estranged (and strange) ex-wife Beth dumps their daughter Jeannie on Matt, father and daughter have a lot of adjusting to do. His budding relationship with attractive production assistant Cathy Breslow is made complicated, while the precocious child is overly accustomed to getting her own way. Matt eventually faces the choice of family vs career in a particularly difficult way.

Dr. Malcolm Sayer, a shy research physician, uses an experimental drug to "awaken" the catatonic victims of a rare disease. Leonard is the first patient to receive the controversial treatment. His awakening, filled with awe and enthusiasm, proves a rebirth for Sayer too, as the exuberant patient reveals life's simple but unutterably sweet pleasures to the introverted doctor.